![]() To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX XR or reduce the dosage. Abrupt discontinuation or rapid dosage reduction of XANAX XR after continued use may precipitate acute withdrawal reactions, which can be life-threatening.Before prescribing XANAX XR and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction. The use of benzodiazepines, including XANAX XR, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death.Follow patients for signs and symptoms of respiratory depression and sedation. ![]() ![]() Limit dosages and durations to the minimum required. Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS ABUSE, MISUSE, AND ADDICTION and DEPENDENCE AND WITHDRAWAL REACTIONS See full prescribing information for complete boxed warning.
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